Montelukast Granules

(Product under development)
Montelukast GranulesMontelukast (trade names Singulair and Montelo-10) is a leukotriene receptor antagonist (LTRA) used for the maintenance treatment of asthma and to relieve symptoms of seasonal allergies.

It is usually administered orally. Montelukast is a CysLT1 antagonist; that it blocks the action of leukotriene D4 (and secondary ligands LTC4 and LTE4) on the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchial tubes by binding to it

This reduces the bronchoconstriction otherwise caused by the leukotriene and results in less inflammation.

Because of its method of operation, it is not useful for the treatment of acute asthma attacks. Again because of its very specific focus of operation, it does not interact with other asthma medications such as theophylline.

Another leukotriene receptor antagonist is zafirlukast (Accolate), taken twice daily. Zileuton (Zyflo), an asthma drug taken four times per day, blocks leukotriene synthesis by inhibiting 5-lipoxygenase, an enzyme of the eicosanoid synthesis pathway.

The Mont in Montelukast stands for Montreal, the place where Merck developed the drug.

Available Form:
Montelukast Granules
Montelukast Pellets

Umang Pharmatech equipments used for production of Montelukast Granules:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Montelukast Granules
Systematic (IUPAC) Name
Montelukast Granules
Montelukast Granules
Chemical data
methyl)cyclopropyl)acetic acid
CAS number : 158966-92-8
ATC code : R03DC03
PubChemr : CID 5281040
DrugBank : APRD00434
ChemSpider : 4444507
KEGG : D08229
ChEBI : CHEBI:50730
Formula : C35H36ClNO3S
Mol. mass : 586.184 g/mol

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