Clonazepam Pellets

(Product under development)
Clonazepam PelletsClonazepam is a benzodiazepine derivative having anticonvulsant, muscle relaxant, and very potent anxiolytic properties. It is marketed by Roche under the trade-names Klonopin in the United States, Rivotril in Australia, Brazil and Canada, and Kriadex in Mexico. Other names such as Ravotril, Rivatril, or Clonex are known throughout the large majority of the rest of the world[citation needed]. Clonazepam is also marketed as Paxam in Australia as a generic brand.

Clonazepam has an unusually long half-life of 18–50 hours, making it generally considered to be among the long-acting benzodiazepines. Clonazepam is a chlorinated derivative ofnitrazepam and therefore a chloro-nitrobenzodiazepine.

Benzodiazepines such as clonazepam have a fast onset of action and high effectiveness rate and low toxicity in overdose but have drawbacks due to adverse reactions including paradoxical effects, drowsiness, and cognitive impairment. Cognitive impairments can persist for at least six months after withdrawal of clonazepam; it is unclear whether full recovery of memory functions occurs.

Other long-term effects of benzodiazepines include tolerance, a benzodiazepine dependence as well as a benzodiazepine withdrawal syndrome occurs in a third of people treated with clonazepam for longer than four weeks.

Clonazepam is classified as a high potency benzodiazepine and is sometimes used as a second line treatment of epilepsy. Clonazepam, like other benzodiazepines, while being first line treatments for acute seizures, are not first line for the long-term treatment of seizures due to the development of tolerance to the anticonvulsant effects.

The benzodiazepine clorazepate may be preferred over clonazepam due to a slower onset of tolerance and availability in slow release formulation to counter fluctuations in blood levels. Clonazepam is also used for the treatment of panic disorder. The pharmacological property of clonazepam as with other benzodiazepines is the enhancement of the neurotransmitter GABA via modulation of the GABAA receptor.

Available Form:
Clonazepam Pellets
Clonazepam Granules

Umang Pharmatech equipments used for production of Clonazepam Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.


Clonazepam Pellets
Systematic (IUPAC) Name
Clonazepam Pellets
Identifiers
Clonazepam Pellets
Chemical data
5-(2-chlorophenyl)-7-nitro-2,3-dihydro-1,4-benzodiazepin-2-one
CAS number : 1622-61-3
ATC code : N03AE01
PubChem : CID 2802
DrugBank : APRD00054
ChemSpider : 2700
UNII : 5PE9FDE8GB
KEGG : D00280
ChEMBL : CHEMBL452
Formula : C15H10ClN3O3
Mol. mass : 315.715 g/mol


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