Diosmin Pellets

(Product under development)
Diosmin PelletsDiosmin is a semisynthetic phlebotropic drug (modified hesperidin), a member of the flavonoid family.

It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) and hemorrhoidal disease (HD), in acute or chronic hemorrhoids, in place of rubber-band ligation, in combination with fiber supplement, or as an adjuvant therapy to hemorrhoidectomy, in order to reduce secondary bleeding. To control internal symptoms of hemorrhoids (piles), it is used with hesperidin.

Clinical studies have been inconclusive and no review articles on its use in vascular disease have been published.

Diosmin is currently a prescription medication in some European countries, and is sold as a nutritional supplement in the United States and the rest of Europe. Diosmin aglycone is diosmetin.

Diosmin has been found to be effective in mitigating hyperglycemia in diabetic rats. It is also speculated that diosmin might have potential in the treatment of neurodegenerative diseases, such as alzheimer's disease, and its anti-inflammatory and anti-apoptotic activity has been demonstrated in neuronal cells, in vitro.

Available Forms:
Diosmin Pellets
Diosmin Granulers

Umang Pharmatech equipments used for production of Diosmin Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Diosmin Pellets
Systematic (IUPAC) name
Diosmin Pellets
Identifiers
Diosmin Pellets
Chemical data
5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)- 7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy -6-[[(2R,3R,4R,5R,6S) -3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one
CAS number : 520-27-4
ATC code : C05CA03
PubChem : CID 5281613
ChemSpider : 4444932
UNII : 7QM776WJ5N
KEGG : D07858
Formula : C28H32O15
Mol. mass : 608.545 g/mol


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