Drotaverine Pellets

(Product under development)
Drotaverine PelletsDrotaverine (INN, also known as drotaverin) is an antispasmodic drug, structurally related to papaverine. Drotaverine is a selective inhibitor of phosphodiesterase 4, and has no anticholinergic effects.[citation needed] Drotaverine has been shown to possess dose-dependant analgesic effects in animal models. One small study has shown drotaverine to be eliminated mainly non-renally.

A few small 2003 studies found drotaverine to be nearly 80% effective in treating renal colic. It has also been studied in accelerating labor by speeding up cervical dilation, but the results have been conflicting.

Drotaverine has been shown to be effective in paracervical block in managing pain during hysteroscopy and endometrial biopsy when administered together with mefenamic acid. IBS patients presenting with predominant diarrhea are more likely to benefit from Buscopan.

Drotaverin has also been tested in combination with rimantadine for antiviral activity against A and B type influenza. Drotaverin has an adverse effects frequency of 0.9%, side effects being relatively uncommon.

Drotaverine in sold under brand name No-Spa (Chinoin Pharmaceutical and Chemical Works, Hungary, a member of the Sanofi-Aventis)

Available Forms:
Drotaverine Pellets
Drotaverine Granulers

Umang Pharmatech equipments used for production of Drotaverine Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Drotaverine Pellets
Systematic (IUPAC) name
Drotaverine Pellets
Identifiers
Drotaverine Pellets
Chemical data
(Z)-1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline
CAS number : 985-12-6
ATC code : A03AD02
PubChem : CID 1712095
DrugBank : DB06751
ChemSpider : 1361582
UNII : 98QS4N58TW
KEGG : D07879
ChEMBL : CHEMBL551978
Formula : C24H31NO4
Mol. mass : 397.507 g/mol


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