Etoposide Pellets

(Product under development)
Etoposide PelletsEtoposide phosphate (brand names: Eposin, Etopophos, Vepesid, VP-16) is an anti-cancer agent. It is known in the laboratory as a topoisomerase poison. Etoposide is often incorrectly referred to as a topoisomerase inhibitor in order to avoid using the term "poison" in a clinical setting.

Unlike enzyme inhibitors, it exploits the normal mechanism of action of the enzyme topoisomerase II, which aids in DNA unwinding, and by doing so causes DNA strands to break.

Cancer cells rely on this enzyme more than healthy cells, since they divide more rapidly. It is used as a form of chemotherapy for cancers such as Ewing's sarcoma, lung cancer, testicular cancer, lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.

It is often given in combination with other drugs. It is also sometimes used in a conditioning regimen prior to a bone marrow or blood stem cell transplant.

Its chemical make-up derives from podophyllotoxin, a toxin found in the American Mayapple.

The name VP-16 likely comes from a compounding of the last name of the chemists who performed early work on the drug (von Wartburg and von Kuhn) and podophyllotoxin.

Another chemist who was integral in the development of podophyllotoxin-based chemotherapeutics was Hartmann F. Stähelin.

Available Form:
Etoposide Pellets
Etoposide Granules

Umang Pharmatech equipments used for production of Etoposide Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Etoposide Pellets
Systematic (IUPAC) Name
Etoposide Pellets
Identifiers
Etoposide Pellets
Chemical data
4'-demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside], 4' -(dihydrogen phosphate)
CAS number : 33419-42-0
ATC code : L01CB01
PubChem : CID 36462
DrugBank : APRD00239
ChemSpider : 33510
UNII : 6PLQ3CP4P3
KEGG : D00125
ChEBI : CHEBI:4911
ChEMBL : CHEMBL44657
Formula : C29H32O13
Mol. mass : 588.557 g/mol


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