Glipizide Pellets

Glipizide PelletsGlipizide is an oral medium-to-long acting anti-diabetic drug from the sulfonylurea class. It is classified as a second generation sulfonylurea, which means that it undergoes enterohepatic circulation.

The structure on the R2 group is a much larger cyclo or aromatic group compared to the 1st generation sulfonylureas. This leads to a once a day dosing that is much less than the first generation, about 100 fold.

Mechanism of action is produced by blocking potassium channels in the beta cells of the islets of Langerhans. By partially blocking the potassium channels, it will increase the time the cell spends in the calcium release stage of cell signaling leading to an increase in calcium.

The increase in calcium will initiate more insulin release from each beta cell.

Available Form:
Glipizide Pellets
Glipizide Granules

Umang Pharmatech equipments used for production of Glipizide Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Glipizide Pellets
Systematic (IUPAC) Name
Glipizide Pellets
Glipizide Pellets
Chemical data
CAS number : 29094-61-9
ATC code : BB07
PubChem : CID 3478
DrugBank : APRD00436
ChemSpider : 3359
KEGG : D00335
Formula : C21H27N5O4S
Mol. mass : 445.536 g/mol

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