Lorazepam Pellets

(Product under development)
Lorazepam Pellets Lorazepam (initially marketed under the brand names Ativan and Temesta) is a high-potency short-to-intermediate-acting 3-hydroxy benzodiazepine drug that has all five intrinsic benzodiazepine effects: anxiolytic, amnesic, sedative/hypnotic, anticonvulsant and muscle relaxant.

Lorazepam is used for the short-term treatment of anxiety, insomnia, acute seizures including status epilepticus and sedation of hospitalised patients, as well as sedation of aggressive patients.

Lorazepam is considered to be a short-acting drug which, similar to other benzodiazepines, exerts its therapeutic as well as adverse effects via its interaction at benzodiazepine binding sites, which are located on GABAA receptors in the central nervous system.

After its introduction in 1977, lorazepam's principal use was in treating anxiety. Among benzodiazepines, lorazepam has a relatively high addictive potential. Lorazepam also has abuse potential; the main types of misuse are for recreational purposes or continued use against medical advice. The sedative-hypnotic and anterograde amnesia properties of lorazepam are sometimes used for criminal purposes.

Long-term effects of benzodiazepines include tolerance, dependence, a benzodiazepine withdrawal syndrome and cognitive impairments which may not completely reverse after cessation of treatment; however, for most patients, cognitive impairment is not severe.

Withdrawal symptoms can range from anxiety and insomnia to seizures and psychosis. Due to tolerance and dependence, lorazepam is recommended for short-term use, 2–4 weeks only.

Adverse effects including anterograde amnesia, depression and paradoxical effects such as excitement or worsening of seizures may occur.

Children and the elderly are more sensitive to the adverse effects of benzodiazepines. Lorazepam impairs body balance and standing steadiness and is associated with falls and hip fractures in the elderly.

Availble Form:
Lorazepam IR Pellets
Lorazepam Granules

Umang Pharmatech equipments used for production of Lorazepam Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Lorazepam Pellets
Systematic (IUPAC) Name
Lorazepam Pellets
Identifiers
Lorazepam Pellets
Chemical data
(RS)-9-chloro-6-(2-chlorophenyl)-4-hydroxy-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one
CAS number : 846-49-1
ATC code : N05BA06
PubChem : CID 3958
DrugBank : APRD00116
ChemSpider : 3821
UNII : O26FZP769L
KEGG : D00365
ChEMBL : CHEMBL580
Synonyms : O-Chloroxazepam, L-Lorazepam Acetate
Formula : C15H10Cl2N2O2
Mol. mass : 321.2 g/mol


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