Losartan Pellets

(Product under development)
Losartan Pellets Losartan is an angiotensin II receptor antagonist drug used mainly to treat high blood pressure (hypertension). Losartan was the first angiotensin II receptor antagonist to be marketed.

Losartan potassium is marketed by Merck & Co. under the trade name Cozaar. As of 2010, losartan is available in generic form.

As with all angiotensin II type 1 receptor (AT1) antagonists, losartan is indicated for the treatment of hypertension.

It may also delay progression of diabetic nephropathy, and is also indicated for the reduction of renal disease progression in patients with type 2 diabetes, hypertension and microalbuminuria (>30 mg/24 hours) or proteinuria (>900 mg/24 hours).

Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most patients (from both efficacy and cost points of view), an angiotensin II receptor antagonist such as losartan is recommended as first-line treatment in patients under the age of 55 who cannot tolerate an ACE inhibitor.

The LIFE study demonstrated losartan was significantly superior to atenolol in the primary prevention of adverse cardiovascular events (myocardial infarction or stroke), with a significant reduction in cardiovascular morbidity and mortality for a comparable reduction in blood pressure.

Availble Form:
Losartan IR Pellets
Losartan Granules

Umang Pharmatech equipments used for production of Losartan Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Losartan Pellets
Systematic (IUPAC) Name
Losartan Pellets
Identifiers
Losartan Pellets
Chemical data
(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol
CAS number : 114798-26-4
ATC code : C09CA01
PubChem : CID 3961
IUPHAR ligand : 590
DrugBank : APRD00052
ChemSpider : 3824
UNII : JMS50MPO89
KEGG : D08146
ChEMBL : CHEMBL191
Formula : C22H23ClN6O
Mol. mass : 422.91


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