Megestrol Acetate Pellets

(Product under development)
Megestrol Acetate Pellets Megestrol is a progesterone derivative with antineoplastic properties used in the treatment of advanced carcinoma of the breast and endometrium. When given in relatively high doses, Megestrol can substantially increase appetite in most individuals, even those with advanced cancer.

It is also used to boost appetite in individuals with other cancers or HIV/AIDS. Megestrol acetate oral suspension (a form of Megestrol) is used primarily as an appetite enhancer. The method of appetite enhancement is not known, but it can cause high blood sugar.

Currently, it is manufactured under the trade name Megace.

Little is known about the drug's chemical interactions. Doses range from 40 mg three times a day, 30 minutes before meals, to 800 mg once a day. Side effects may include diarrhea, rash, and impotence. Males may have some feminizing effects such as gynecomastia (breast development).

It is a category X U.S. Food and Drug Administration drug, which means cannot be used in pregnancy as it crosses the placenta and malignantly affects the fetus.

Available Form:
Megestrol Acetate Pellets
Megestrol Acetate Granules

Umang Pharmatech equipments used for production of Megestrol Acetate Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.


Megestrol Acetate Pellets
Systematic (IUPAC) Name
Megestrol Acetate Pellets
Identifiers
Megestrol Acetate Pellets
Chemical data
17-acetyl-17-hydroxy-6,10, 13-trimethyl-2,8,9,11,12,14,15,16- octahydro-1H-cyclopenta[ a] phenanthren-3-one
CAS number : 3562-63-8
ATC code : G03AC05 G03DB02, L02AB01
PubChem : CID 19090
DrugBank : APRD01092
ChemSpider : 18023
UNII : EA6LD1M70M
KEGG : D08167
ChEMBL : CHEMBL1201139
Formula : C22H30O3
Mol. mass : 342.472 g/mol


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