Nicotinic Acid Pellets

(Product under development)
Nicotinic Acid Pellets Nicotinic Acid (also known as vitamin B3, Niacin and vitamin PP) is an organic compound with the formula C6H5NO2 and, depending on the definition used, one of the forty to eighty essential human nutrients.

This colorless, water-soluble solid is a derivative of pyridine, with a carboxyl group (COOH) at the 3-position. Other forms of vitamin B3 include the corresponding amide, nicotinamide ("niacinamide"), where the carboxyl group has been replaced by a carboxamide group (CONH2), as well as more complex amides and a variety of esters.

The terms niacin, nicotinamide, and vitamin B3 are often used interchangeably to refer to any member of this family of compounds, since they have similar biochemical activity. Nicotinic Acid is commercialised by Sepracor under the name Niaspan and by OdanLaboratories under the name Ni-odan.

Nicotinic Acid cannot be directly converted to nicotinamide, but both compounds could be converted to NAD and NADP in vivo. Although the two are identical in their vitamin activity, nicotinamide does not have the same pharmacological effects (lipid modifying effects) as niacin; these effects occur as side effects of niacin's conversion. Nicotinamide does not reduce cholesterol or cause flushing. Nicotinamide may be toxic to the liver at doses exceeding 3 g/day for adults.

Nicotinic Acid is a precursor to NAD+/NADH and NADP+/NADPH, which play essential metabolic roles in living cells. Nicotinic Acid is involved in both DNA repair, and the production of steroid hormones in the adrenal gland.

Nicotinic Acid is one of five vitamins associated with a pandemic deficiency disease: niacin deficiency (pellagra), vitamin C deficiency (scurvy), thiamin deficiency (beriberi), vitamin D deficiency (rickets), vitamin A deficiency (night blindness and other symptoms).

Nicotinic Acid has been used to increase levels of HDL cholesterol in the blood and has been found to modestly decrease the risk of cardiovascular events in a number of controlled human trials. However, in a recent trial AIM-HIGH, a slow-release form of niacin was found to have no effect on cardiovascular event and stroke risk in a group of patients with LDL levels already well-controlled by a statin drug, and the trial was halted prematurely on evidence that niacin addition actually increased stroke risk in this group. The role of niacin in treating cardiovascular risk remains under debate.

Available Form:
Nicotinic Acid Pellets
Nicotinic Acid Granules

Umang Pharmatech equipments used for production of Nicotinic Acid Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Nicotinic Acid Pellets
Systematic (IUPAC) Name
Nicotinic Acid Pellets
Identifiers
Nicotinic Acid Pellets
Chemical data
Nicotinic acid[citation needed
CAS number : 59-67-6
PubChem : 938
ChemSpider : 913
UNII : 2679MF687A
EC number : 200-441-0
DrugBank : DB00627
KEGG : D00049
MeSH : Niacin
ChEBI : CHEBI:15940
ChEMBL : CHEMBL573
Formula : C6NH5O2
Mol. mass : 123.1094 g mol-1


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