Orphenadrine Pellets

(Product under development)
Orphenadrine PelletsOrphenadrine (sold under the brand names: Norflex, Mephenamin, Disipal, Banflex, Flexon, Biorphen, Brocasipal, Dolan and others) is an anticholinergic drug of the ethanolamine antihistamine class with prominent CNS and peripheral actions used to treat painful muscle spasms, other similar conditions, as well as the treatment of some aspects of Parkinson's Disease.

It is closely related to diphenhydramine. Therefore, it is related to other drugs used for Parkinson's like benztropine and trihexyphenidyl, and it is also structurally related to nefopam, which is a centrally-acting yet non-opioid analgesic.

The combination of anticholinergic effects and CNS penetration make orphenadrine useful for pain of all etiologies, including pain from: radiculopathy, muscle pain, headaches, and many other types. Some patients report that it feels like orphenadrine and similar drugs help both NSAIDs and opioids find the pain. Orphenadrine has approximately 58% of the anticholinergic potency of atropine at equivalent doses.

Orphenadrine is most often used against pain and muscle spasm of various etiologies including lumbago, sciatica, and injury. It is quite useful against allergic symptoms and other histamine-related effects, such as those from hay fever, other allergies, and histamine release from many opioid analgesics.

Orphenadrine is in many cases helpful against migraine and cluster headaches and is also used for treating some aspects of Parkinson's Disease, including side effects caused by the main therapy in place. Where available for prescription compounding, orphenadrine can also be prepared for topical administration and works slightly better than diphenhydramine for this purpose.

The orphenadrine salt used for Parkinsonism is the hydrochloride, whereas the muscle relaxant tablet are the citrate. The manufacturers' descriptions of orphenadrine indicate that the salts are not interchangeable; one reason may be that the citrate can be irritating when injected.

Euphoria is an effect reported by many patients and orphenadrine has been investigated for use against depression, as first reported in June 1958 in the American Journal of Psychiatry.

Like many first-generation antihistamines and chemically-similar anticholinergics, orphenadrine can also cause excitement and insomnia, particularly in children and the elderly. Orphenadrine also works on smooth muscle in a manner identical to that of dicyclomine, brand name Bentyl, and will impact Irritable Bowel Syndrome in a similar fashion.

Available Form:
Orphenadrine Pellets
Orphenadrine Granules

Umang Pharmatech equipments used for production of Orphenadrine Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.


Orphenadrine Pellets
Systematic (IUPAC) Name
Orphenadrine Pellets
Identifiers
Orphenadrine Pellets
Chemical data
N,N-dimethyl-2-[(2-methylphenyl)- phenyl-methoxy]-ethanamine
CAS number : 83-98-7
ATC code : M03BC01 N04AB02
PubChem : CID 4601
DrugBank : APRD00097
ChemSpider : 4440
UNII : AL805O9OG9
KEGG : D08305
ChEBI : CHEBI:7789
ChEMBL : CHEMBL900
Formula : C18H23NO
Mol. mass : 269.381 g/mol


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