Primidone Pellets

(Product under development)
Primidone PelletsPrimidone is an anticonvulsant of the pyrimidinedione class, the active metabolites of which, phenobarbital (major) and phenylethylmalonamide (PEMA) (minor), are also anticonvulsants.

It is used mainly to treat complex partial, simple partial, generalized tonic-clonic seizures, myoclonic, and akinetic seizures and since the 1980s it has been a valuable alternative to propranolol in the treatment of essential tremor. Unlike other anticonvulsants such as carbamazepine and valproic acid, primidone is rarely used in the treatment of bipolar disorder or any other psychiatric problem.

It is also not widely used in treatment of neuropathic pain, trigeminal neuralgia, or migraine. Primidone has been occasionally used to treat long QT syndrome, cerebral palsy, and athetosis.

Primidone was once a mainstay anticonvulsant in the treatment of partial and generalized seizures and was the treatment of choice for secondarily generalized seizures originating in the temporal lobes, especially when combined with phenytoin, but by the early 1980s, carbamazepine had surpassed it in popularity due to the latter's lower incidence of sedation.


Unlike many other anticonvulsants, primidone works via interactions with voltage-gated sodium channels which inhibit high-frequency repetitive firing of action potentials. It is much less toxic in overdose than phenobarbital.

Along with carbamazepine, phenobarbital, and phenytoin, primidone is an inducer of metabolic enzymes in the liver, which means that it accelerates the metabolism of many other pharmaceuticals. Like other anticonvulsants that entered the market before 1989, primidone has been associated with hyperhomocysteinemia, folate deficiency and its various symptoms (birth defects, depression, and megaloblastic anemia), reduced calcium absorption, and various bone diseases. It also shares with most other anticonvulsants the tendency to cause sedation.

Available Form:
Primidone Pellets
Primidone Granules

Umang Pharmatech equipments used for production of Primidone Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.



Primidone Pellets
Systematic (IUPAC) Name
Primidone Pellets
Identifiers
Primidone Pellets
Chemical data
5-ethyl-5-phenyl-hexahydropyrimidine-4,6-dione
CAS number : 125-33-7
ATC code : N03AA03
PubChem : CID 4909
DrugBank : APRD00549
ChemSpider : 4740
UNII : 13AFD7670Q
KEGG : D00474
ChEMBL : CHEMBL856
Formula : C12H14N2O2
Mol. mass : 218.252 g/mol


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