Rifampicin Pellets

(Product under development)
Rifampicin PelletsRifampicin or rifampin (USAN) is a bactericidal antibiotic drug of the rifamycin group. It is a semisynthetic compound derived from Amycolatopsis rifamycinica (formerly known as Amycolatopsis mediterranei and Streptomyces mediterranei). Rifampicin may be abbreviated R, RMP, RA, RF, or RIF (US).

In 1957, a sample of soil coming from a pine wood on the French Riviera was brought for analysis to the Lepetit Pharmaceuticals research lab in Milan, Italy. There, a research group headed by Prof. Piero Sensi (1920-) discovered a new bacterium.

This new species appeared immediately of great scientific interest since it was producing a new class of molecules with antibiotic activity. Because Prof.

Sensi and some of his fellow researchers were particularly fond of the French crime story Rififi (about a jewel heist and rival gangs), they decided to call these compounds "rifamycins". After two years of attempts in order to obtain more stable semi-synthetic products, in 1959 a new molecule with high efficacy and good tolerability was produced and was named "rifampicin".

Rifampicin is also known as rifaldazine, R/AMP, rofact (in Canada), and rifampin in the United States. There are various types of rifamycins from which this is derived, but the rifampicin form, with a 4-methyl-1-piperazinaminyl group, is by far the most clinically effective.

Rifampicin is an intensely red solid, and the small fraction which reaches body fluids is known for imparting a harmless red-orange color to the urine (and to a lesser extent, also sweat and tears) of users, for a few hours after a dose. Maximal concentrations in the blood are decreased by about a third when the antibiotic is taken with food.[4] Rifampicin is one of the antibiotics that are used when treating a BCG-oma

Available Form:
Rifampicin Pellets
Rifampicin Granules

Umang Pharmatech equipments used for production of Rifampicin Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.


Rifampicin Pellets
Systematic (IUPAC) Name
Rifampicin Pellets
Identifiers
Rifampicin Pellets
Chemical data
(7S,9E,11S,12R,13S,14R,15R,16R,
17S,18S,19E,21Z)-2,15,17,27,29
-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl
-26-{(E)-[(4-methylpiperazin-1-yl)imino]methyl}-6,23-dioxo-8,30
-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]
triaconta-1(28),2,4,9,19,21,25(29),26-octaen-13-yl acetate
CAS number : 13292-46-1
ATC code : J04AB02 QJ54AB02
PubChem : CID 5360416
DrugBank : APRD00207
ChemSpider : 4529237
UNII : VJT6J7R4TR
KEGG : D00211
ChEBI : CHEMBL180
Formula : C43H58N4O12
Mol. mass : 822.94 g/mol


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