Sertraline Pellets

(Product under development)
Sertraline PelletsSertraline hydrochloride (brand names Zoloft and Lustral) is an antidepressant of theselective serotonin reuptake inhibitor (SSRI) class.

It was introduced to the market by Pfizer in 1991. Sertraline is primarily used to treat major depression in adult outpatients as well asobsessive–compulsive, panic, and social anxiety disorders in both adults and children.

In 2007, it was the most prescribed antidepressant on the U.S. retail market, with 29,652,000 prescriptions.

The efficacy of sertraline for depression is similar to that of older tricyclic antidepressants, but its side effects are much less pronounced.

Differences with newer antidepressants are subtler and also mostly confined to side effects. Evidence suggests that sertraline may work better thanfluoxetine (Prozac) for some subtypes of depression.

Sertraline is highly effective for the treatment of panic disorder, but cognitive behavioral therapy is a better treatment for obsessive-compulsive disorder, whether by itself or in combination with sertraline.

Although approved forsocial phobia and posttraumatic stress disorder, sertraline leads to only modest improvement in these conditions. Sertraline also alleviates the symptoms of premenstrual dysphoric disorderand can be used in sub-therapeutic doses or intermittently for its treatment.

Sertraline shares the common side effects and contraindications of other SSRIs, with high rates of nausea, diarrhea, insomnia, and sexual side effects; however, its effects on cognition are mild. The unique effect of sertraline on dopaminergic neurotransmission may be related to its favorable effects on cognition.

In pregnant women taking sertraline, the drug was present in significant concentrations in fetal blood, and was also associated with a higher rate of various birth defects. Similarly to other antidepressants, the use of sertraline for depression may be associated with a higher rate of suicidal behavior. Due to the rarity of this side effect, statistically significant data are difficult to obtain, and suicidal behavior continues to be a subject of controversy.

Available Form:
Sertraline Pellets
Sertraline Granules

Umang Pharmatech equipments used for production of Sertraline Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Sertraline Pellets
Systematic (IUPAC) Name
Sertraline Pellets
Sertraline Pellets
Chemical data
CAS number : 79617-96-2
ATC code : N06AB06
PubChem : CID 68617
DrugBank : DB01104
ChemSpider : 61881
KEGG : D02360
Formula : C17H17Cl2N
Mol. mass : 306.229 g/mol