Tamoxifen Pellets

Tamoxifen PelletsTamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, hence tamoxifen may be characterized as a mixed agonist/antagonist.

It has been the standard endocrine (anti-estrogen) therapy for hormone receptor-positive early breast cancer in pre-menopausal women, although aromatase inhibitors have been proposed.

Some breast cancer cells require estrogen to grow. Estrogen binds to and activates the estrogen receptor in these cells. Tamoxifen is metabolized into compounds that also bind to the estrogen receptor but do not activate it.

Because of this competitive antagonism, tamoxifen acts like a key broken off in the lock that prevents any other key from being inserted, preventing estrogen from binding to its receptor. Hence breast cancer cell growth is blocked.

Tamoxifen was discovered by ICI Pharmaceuticals[2] (now AstraZeneca) and is sold under the trade names Nolvadex, Istubal, and Valodex. However, the drug, even before its patent expiration, was and still is widely referred to by its generic name "tamoxifen."

Available Form:
Tamoxifen Pellets
Tamoxifen Granules

Umang Pharmatech equipments used for production of Tamoxifen Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Tamoxifen Pellets
Systematic (IUPAC) Name
Tamoxifen Pellets
Identifiers
Tamoxifen Pellets
Chemical data
(Z)-2-[4-(1,2-diphenylbut-1-enyl)phenoxy]-N,N-dimethylethanamine
CAS number : 10540-29-1
ATC code : L02BA01
PubChem : CID 2733526
DrugBank : APRD00123
ChemSpider : 2015313
UNII : 094ZI81Y45
KEGG : D08559
ChEMBL : CHEMBL83
Formula : C26H29NO
Mol. mass : 371.515 g/mol 563.638 g/mol (citrate salt)


* All transactions are carried out in conformity with patent laws applicable in the user country. Active pharmaceutical ingredients or formulations thereof will not be supplied in countries where the same is under patent protection except as and if permitted under law of the country for research and development purposes only.
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