Thalidomide Pellets

Thalidomide PelletsThalidomide was introduced as a sedative drug in the late 1950s and typically used to cure morning sickness. In 1961, it was withdrawn due to teratogenicity andneuropathy.

There is now a growing clinical interest in thalidomide, and it is introduced as an immunomodulatory agent used primarily, combined with dexamethasone, to treat multiple myeloma.

The drug is a potent teratogen in zebrafish, chickens, rabbits and primates including humans: severe birth defects may result if the drug is taken during pregnancy.

Thalidomide was sold in a number of countries across the world from 1957 until 1961 when it was withdrawn from the market after being found to be a cause of birth defects in what has been called "one of the biggest medical tragedies of modern times". It is not known exactly how many worldwide victims of the drug there have been, although estimates range from 10,000 to 20,000.

Since then thalidomide has been found to be a valuable treatment for a number of medical conditions and it is being prescribed again in a number of countries, although its use remains controversial, including its testing in the developing world. The thalidomide tragedy led to much stricter testing being required for drugs and pesticides before they can be licensed.

Available Form:
Thalidomide Pellets
Thalidomide Granules

Umang Pharmatech equipments used for production of Thalidomide Pellets:
Drug Layering, Fluid Bed Dryer, Fluid Bed Coater, Sifter & Blender, Extruder and Twin spheronizer.

Thalidomide Pellets
Systematic (IUPAC) Name
Thalidomide Pellets
Identifiers
Thalidomide Pellets
Chemical data
(RS)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
CAS number : 50-35-1
ATC code : L04AX02
PubChem : CID 5426
DrugBank : DB01041
ChemSpider : 5233
UNII : 4Z8R6ORS6L
KEGG : D00754
ChEMBL : CHEMBL468
Formula : C13H10N2O4
Mol. mass : 258.23 g/mol


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